Common sense of using spray drying granulator
With the deepening of the concept of quality originating from design, the research and development of drug production processes and pilot testing are also receiving increasing attention from the pharmaceutical industry. From the perspective of consumers, purity is the most important attribute of drugs; From the perspective of pharmaceutical manufacturers, equipment should have a certain degree of flexibility in functionality, especially experimental or pilot equipment.
It is understood that the spray drying granulator is a new one-step granulator integrating spray drying technology and fluidized bed granulator technology. It uses a negative pressure suction of an induced draft fan to dry and aggregate droplets into particles, and can adjust the particle size according to requirements. Widely used in granulation and drying operations in pharmaceutical, chemical, food, feed and other industries. Suitable for one-step granulation and drying of tablets, granules, capsule granules, low sugar, sugar free small dose granules, sustained-release granules, especially traditional Chinese medicine extracts.
According to experts, the equipment integrates mixing, spray drying, granulation and particle coating functions; It can produce micro auxiliary materials, low dosage, sugar free or low sugar traditional Chinese patent medicines and simple preparations products; The granules are instant soluble, the granules are easy to dissolve, and the tablets are easy to disintegrate, meeting the requirements of "GMP". In many aspects such as granulation speed, particle quality, and automation level, another important step has been taken towards the international advanced level.
Necessary preparations shall be made before starting the spray drying granulator. Firstly, check if the bearings and sealing parts of each device are loose, the lubricating oil condition of each mechanical component, and whether the water, air, and slurry pipe valve ports are in the required position. Then turn on the power supply to check whether the voltage and instrument are normal, and finally check the amount and concentration of slurry in the slurry mixing drum. If any problem occurs, it should be eliminated in time.
Industry insiders remind that after the equipment operates normally, it is necessary to regularly receive materials, check the operation of various systems, record various process parameters, and pay attention to cleaning the vibrating screen. In case of emergency, the equipment must be immediately shut down, and the supply fan and material pump should be shut down first. If there is a sudden power outage, the gas turbine should be pulled out to naturally cool the tower, and then the sewage valve should be opened to discharge all the slurry in the slurry pipeline and clean the equipment.
It is becoming increasingly widespread and has considerable development prospects. Chinese granulator enterprises should be based on technology, absorb and introduce advanced domestic and foreign technologies, and continuously develop new products.
With the deepening of the concept of quality originating from design, the research and development of drug production processes and pilot testing are also receiving increasing attention from the pharmaceutical industry. From the perspective of consumers, purity is the most important attribute of drugs; From the perspective of pharmaceutical manufacturers, equipment should have a certain degree of flexibility in functionality, especially experimental or pilot equipment.
It is understood that the spray drying granulator is a new one-step granulator integrating spray drying technology and fluidized bed granulation technology. It uses a negative pressure suction of an induced draft fan to dry and aggregate droplets into particles, and can adjust the particle size according to requirements. Widely used in granulation and drying operations in pharmaceutical, chemical, food, feed and other industries. Suitable for one-step granulation and drying of tablets, granules, capsule granules, low sugar, sugar free small dose granules, sustained-release granules, especially traditional Chinese medicine extracts.
According to experts, the equipment integrates mixing, spray drying, granulation and particle coating functions; It can produce micro auxiliary materials, low dosage, sugar free or low sugar traditional Chinese patent medicines and simple preparations products; The granules are instant soluble, the granules are easy to dissolve, and the tablets are easy to disintegrate, meeting the requirements of "GMP". In many aspects such as granulation speed, particle quality, and automation level, another important step has been taken towards the international advanced level.
Necessary preparations shall be made before starting the spray drying granulator. Firstly, check if the bearings and sealing parts of each device are loose, the lubricating oil condition of each mechanical component, and whether the water, air, and slurry pipe valve ports are in the required position. Then turn on the power supply to check whether the voltage and instrument are normal, and finally check the amount and concentration of slurry in the slurry mixing drum. If any problem occurs, it should be eliminated in time.
Industry insiders remind that after the equipment operates normally, it is necessary to regularly receive materials, check the operation of various systems, record various process parameters, and pay attention to cleaning the vibrating screen. In case of emergency, the equipment must be immediately shut down, and the supply fan and material pump should be shut down first. If there is a sudden power outage, the gas turbine should be pulled out to naturally cool the tower, and then the sewage valve should be opened to discharge all the slurry in the slurry pipeline and clean the equipment.
It is becoming increasingly widespread and has considerable development prospects. Chinese granulator enterprises should be based on technology, absorb and introduce advanced domestic and foreign technologies, and continuously develop new products.
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